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This game also comes with an Free Spins bonus with multipliers up to 500x your bet. A practical trial that employs a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However too much heterogeneity could lead to problems with the design of the trial. Pragmatic Play is also a major player in the live casino market, providing an array of table games that are classic such as Blackjack and Roulette in various variations. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience as well as a broad variety of betting options via virtual. The company also has created several interactive game shows to make online gambling enjoyable. Some of these shows are broadcast live and others are hosted by famous personalities from the field. 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Its latest releases include Wolves, a 5-reel video slot with a healthy RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat. Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be a great method to determine the causality between the intervention and its effects. However, they should not, be used to replace explanatory studies. The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes recruitment, design, implementation of the intervention and its follow-up. The number of pragmatic trials is growing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.